Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation
Identifieur interne : 002551 ( Main/Exploration ); précédent : 002550; suivant : 002552Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation
Auteurs : Ali Danesh [Canada] ; Cheryl M. Cameron [Canada] ; Alberto J. Le N [République populaire de Chine] ; Longsi Ran [Canada] ; Luoling Xu [Canada] ; Yuan Fang [Canada] ; Alyson A. Kelvin [Canada, Italie] ; Thomas Rowe [Canada] ; Honglin Chen [République populaire de Chine] ; Yi Guan [République populaire de Chine] ; Colleen B. Jonsson [États-Unis] ; Mark J. Cameron [Canada] ; David J. Kelvin [Canada, République populaire de Chine, Italie]Source :
- Virology [ 0042-6822 ] ; 2010.
Descripteurs français
- KwdFr :
- Analyse de profil d'expression de gènes, Analyse de séquence d'ADN, Animaux, Données de séquences moléculaires, Facteur de transcription STAT-1 (génétique), Facteur de transcription STAT-1 (métabolisme), Furets (virologie), Humains, Interféron alpha (administration et posologie), Interféron alpha (immunologie), Modèles animaux de maladie humaine, Mâle, Protéines (génétique), Protéines (métabolisme), Protéines recombinantes, Régulation de l'expression des gènes, Régulation positive, Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (pathogénicité).
- MESH :
- administration et posologie : Interféron alpha.
- génétique : Facteur de transcription STAT-1, Protéines.
- immunologie : Interféron alpha, Syndrome respiratoire aigu sévère.
- métabolisme : Facteur de transcription STAT-1, Protéines.
- pathogénicité : Virus du SRAS.
- virologie : Furets, Syndrome respiratoire aigu sévère.
- Analyse de profil d'expression de gènes, Analyse de séquence d'ADN, Animaux, Données de séquences moléculaires, Humains, Modèles animaux de maladie humaine, Mâle, Protéines recombinantes, Régulation de l'expression des gènes, Régulation positive.
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Ferrets (virology), Gene Expression Profiling, Gene Expression Regulation, Humans, Interferon alpha-2, Interferon-alpha (administration & dosage), Interferon-alpha (immunology), Male, Molecular Sequence Data, Proteins (genetics), Proteins (metabolism), Recombinant Proteins, SARS Virus (pathogenicity), STAT1 Transcription Factor (genetics), STAT1 Transcription Factor (metabolism), Sequence Analysis, DNA, Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Up-Regulation.
- MESH :
- chemical , administration & dosage : Interferon-alpha.
- chemical , genetics : Proteins, STAT1 Transcription Factor.
- chemical , immunology : Interferon-alpha.
- chemical , metabolism : Proteins, STAT1 Transcription Factor.
- chemical : Interferon alpha-2, Recombinant Proteins.
- immunology : Severe Acute Respiratory Syndrome.
- pathogenicity : SARS Virus.
- virology : Ferrets, Severe Acute Respiratory Syndrome.
- Animals, Disease Models, Animal, Gene Expression Profiling, Gene Expression Regulation, Humans, Male, Molecular Sequence Data, Sequence Analysis, DNA, Up-Regulation.
Abstract
Type I interferons (IFNs) are essential to the clearance of viral diseases, however, a clear distinction between genes upregulated by direct virus–cell interactions and genes upregulated by secondary IFN production has not been made. Here, we investigated differential gene regulation in ferrets upon subcutaneous administration of IFN-α2b and during SARS-CoV infection.
Url:
DOI: 10.1016/j.virol.2010.10.002
PubMed: 21035159
PubMed Central: 7111932
Affiliations:
- Canada, Italie, République populaire de Chine, États-Unis
- Kentucky, Ontario
- Toronto
- Université de Toronto
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Le document en format XML
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Le N</name><affiliation wicri:level="1"><nlm:aff id="af0020">International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031</wicri:regionArea><wicri:noRegion>515031</wicri:noRegion></affiliation></author><author><name sortKey="Ran, Longsi" sort="Ran, Longsi" uniqKey="Ran L" first="Longsi" last="Ran">Longsi Ran</name><affiliation wicri:level="1"><nlm:aff id="af0005">Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Luoling" sort="Xu, Luoling" uniqKey="Xu L" first="Luoling" last="Xu">Luoling Xu</name><affiliation wicri:level="1"><nlm:aff id="af0005">Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Fang, Yuan" sort="Fang, Yuan" uniqKey="Fang Y" first="Yuan" last="Fang">Yuan Fang</name><affiliation wicri:level="1"><nlm:aff id="af0005">Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="af0010">Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Kelvin, Alyson A" sort="Kelvin, Alyson A" uniqKey="Kelvin A" first="Alyson A." last="Kelvin">Alyson A. Kelvin</name><affiliation wicri:level="1"><nlm:aff id="af0015">Immune Diagnostics & Research, IDR , MaRS Centre, 101 College Street, Suite 200, Toronto, ON, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Immune Diagnostics & Research, IDR , MaRS Centre, 101 College Street, Suite 200, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af0035">SaRD, Sardinia Research and Development srl, Porto Conte Ricerche Research Centre, S.P. 55 Porto Conte Capo Caccia km 8,400, Loc. Tramariglio, 07041, Alghero (SS), Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>SaRD, Sardinia Research and Development srl, Porto Conte Ricerche Research Centre, S.P. 55 Porto Conte Capo Caccia km 8,400, Loc. Tramariglio, 07041, Alghero (SS)</wicri:regionArea><wicri:noRegion>Alghero (SS)</wicri:noRegion></affiliation></author><author><name sortKey="Rowe, Thomas" sort="Rowe, Thomas" uniqKey="Rowe T" first="Thomas" last="Rowe">Thomas Rowe</name><affiliation wicri:level="1"><nlm:aff id="af0005">Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name><affiliation wicri:level="1"><nlm:aff id="af0020">International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031</wicri:regionArea><wicri:noRegion>515031</wicri:noRegion></affiliation></author><author><name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name><affiliation wicri:level="1"><nlm:aff id="af0020">International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031</wicri:regionArea><wicri:noRegion>515031</wicri:noRegion></affiliation></author><author><name sortKey="Jonsson, Colleen B" sort="Jonsson, Colleen B" uniqKey="Jonsson C" first="Colleen B." last="Jonsson">Colleen B. Jonsson</name><affiliation wicri:level="2"><nlm:aff id="af0025">Center for Predictive Medicine, 950 N. Hurstbourne Pkwy, Louisville, KY 40222, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Predictive Medicine, 950 N. Hurstbourne Pkwy, Louisville, KY 40222</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Cameron, Mark J" sort="Cameron, Mark J" uniqKey="Cameron M" first="Mark J." last="Cameron">Mark J. Cameron</name><affiliation wicri:level="1"><nlm:aff id="af0005">Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Kelvin, David J" sort="Kelvin, David J" uniqKey="Kelvin D" first="David J." last="Kelvin">David J. Kelvin</name><affiliation wicri:level="1"><nlm:aff id="af0005">Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada M5G 1L7</nlm:aff><country>Canada</country><wicri:regionArea>Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af0020">International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515031</wicri:regionArea><wicri:noRegion>515031</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af0030">Department of Biomedical Sciences, University of Sassari, Sassari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical Sciences, University of Sassari, Sassari</wicri:regionArea><wicri:noRegion>Sassari</wicri:noRegion></affiliation></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><idno type="eISSN">1096-0341</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Ferrets (virology)</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation</term><term>Humans</term><term>Interferon alpha-2</term><term>Interferon-alpha (administration & dosage)</term><term>Interferon-alpha (immunology)</term><term>Male</term><term>Molecular Sequence Data</term><term>Proteins (genetics)</term><term>Proteins (metabolism)</term><term>Recombinant Proteins</term><term>SARS Virus (pathogenicity)</term><term>STAT1 Transcription Factor (genetics)</term><term>STAT1 Transcription Factor (metabolism)</term><term>Sequence Analysis, DNA</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Up-Regulation</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Analyse de séquence d'ADN</term><term>Animaux</term><term>Données de séquences moléculaires</term><term>Facteur de transcription STAT-1 (génétique)</term><term>Facteur de transcription STAT-1 (métabolisme)</term><term>Furets (virologie)</term><term>Humains</term><term>Interféron alpha (administration et posologie)</term><term>Interféron alpha (immunologie)</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Protéines (génétique)</term><term>Protéines (métabolisme)</term><term>Protéines recombinantes</term><term>Régulation de l'expression des gènes</term><term>Régulation positive</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Interferon-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Proteins</term><term>STAT1 Transcription Factor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Interferon-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Proteins</term><term>STAT1 Transcription Factor</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Interferon alpha-2</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Interféron alpha</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de transcription STAT-1</term><term>Protéines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Interféron alpha</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de transcription STAT-1</term><term>Protéines</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Furets</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Ferrets</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation</term><term>Humans</term><term>Male</term><term>Molecular Sequence Data</term><term>Sequence Analysis, DNA</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Analyse de séquence d'ADN</term><term>Animaux</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Protéines recombinantes</term><term>Régulation de l'expression des gènes</term><term>Régulation positive</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Type I interferons (IFNs) are essential to the clearance of viral diseases, however, a clear distinction between genes upregulated by direct virus–cell interactions and genes upregulated by secondary IFN production has not been made. Here, we investigated differential gene regulation in ferrets upon subcutaneous administration of IFN-α2b and during SARS-CoV infection. <italic>In vivo</italic> experiments revealed that IFN-α2b causes STAT1 phosphorylation and upregulation of abundant IFN response genes (IRGs), chemokine receptors, and other genes that participate in phagocytosis and leukocyte transendothelial migration. During infection with SARS-CoV not only a variety of IRGs were upregulated, but also a significantly broader range of genes involved in cell migration and inflammation. This work allowed dissection of several molecular signatures present during SARS-CoV which are part of a robust IFN antiviral response. These signatures can be useful markers to evaluate the status of IFN responses during a viral infection and specific features of different viruses.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Barclay, J L" uniqKey="Barclay J">J.L. 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Weiss</name></author><author><name sortKey="Mcmichael, A J" uniqKey="Mcmichael A">A.J. McMichael</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>Italie</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Kentucky</li><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Danesh, Ali" sort="Danesh, Ali" uniqKey="Danesh A" first="Ali" last="Danesh">Ali Danesh</name></noRegion><name sortKey="Cameron, Cheryl M" sort="Cameron, Cheryl M" uniqKey="Cameron C" first="Cheryl M." last="Cameron">Cheryl M. Cameron</name><name sortKey="Cameron, Mark J" sort="Cameron, Mark J" uniqKey="Cameron M" first="Mark J." last="Cameron">Mark J. Cameron</name><name sortKey="Danesh, Ali" sort="Danesh, Ali" uniqKey="Danesh A" first="Ali" last="Danesh">Ali Danesh</name><name sortKey="Fang, Yuan" sort="Fang, Yuan" uniqKey="Fang Y" first="Yuan" last="Fang">Yuan Fang</name><name sortKey="Fang, Yuan" sort="Fang, Yuan" uniqKey="Fang Y" first="Yuan" last="Fang">Yuan Fang</name><name sortKey="Kelvin, Alyson A" sort="Kelvin, Alyson A" uniqKey="Kelvin A" first="Alyson A." last="Kelvin">Alyson A. Kelvin</name><name sortKey="Kelvin, David J" sort="Kelvin, David J" uniqKey="Kelvin D" first="David J." last="Kelvin">David J. Kelvin</name><name sortKey="Ran, Longsi" sort="Ran, Longsi" uniqKey="Ran L" first="Longsi" last="Ran">Longsi Ran</name><name sortKey="Rowe, Thomas" sort="Rowe, Thomas" uniqKey="Rowe T" first="Thomas" last="Rowe">Thomas Rowe</name><name sortKey="Xu, Luoling" sort="Xu, Luoling" uniqKey="Xu L" first="Luoling" last="Xu">Luoling Xu</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Le N, Alberto J" sort="Le N, Alberto J" uniqKey="Le N A" first="Alberto J." last="Le N">Alberto J. Le N</name></noRegion><name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name><name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name><name sortKey="Kelvin, David J" sort="Kelvin, David J" uniqKey="Kelvin D" first="David J." last="Kelvin">David J. Kelvin</name></country><country name="Italie"><noRegion><name sortKey="Kelvin, Alyson A" sort="Kelvin, Alyson A" uniqKey="Kelvin A" first="Alyson A." last="Kelvin">Alyson A. Kelvin</name></noRegion><name sortKey="Kelvin, David J" sort="Kelvin, David J" uniqKey="Kelvin D" first="David J." last="Kelvin">David J. Kelvin</name></country><country name="États-Unis"><region name="Kentucky"><name sortKey="Jonsson, Colleen B" sort="Jonsson, Colleen B" uniqKey="Jonsson C" first="Colleen B." last="Jonsson">Colleen B. Jonsson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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